The Fountainhead

                                           Seat of female libido revealed

The precise part of the brain likely to be the seat of heterosexual desire in women has been revealed by experiments on mice.

The study confirms that the hormone oestrogen is vital for arousal, but only in the specific area of the brain called the ventromedial nucleus (VMN) in the hypothalamus.

Sonoko Ogawa of the University of Tsukuba in Japan and her collaborators in the US discovered this by blocking the effects of oestrogen exclusively in that part of the brain in mice. They did this with tiny slugs of genetic material called small hairpin RNAs designed to block production of oestrogen receptor alpha, the molecule where oestrogen docks on cells in the VMN and elsewhere in the body.

They used a harmless virus to shuttle the RNAs exclusively into the VMN, so that oestrogen signals would only be blocked there and nowhere else in the body. The effect was dramatic - the females refused to have sex.

                                    So, that's where all the trouble starts, huh?

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                          Seat of female libido revealed

by Andy Coghlan

The precise part of the brain likely to be the seat of heterosexual desire in women has been revealed by experiments on mice.

The study confirms that the hormone oestrogen is vital for arousal, but only in the specific area of the brain called the ventromedial nucleus (VMN) in the hypothalamus.

Sonoko Ogawa of the University of Tsukuba in Japan and her collaborators in the US discovered this by blocking the effects of oestrogen exclusively in that part of the brain in mice. They did this with tiny slugs of genetic material called small hairpin RNAs designed to block production of oestrogen receptor alpha, the molecule where oestrogen docks on cells in the VMN and elsewhere in the body.

They used a harmless virus to shuttle the RNAs exclusively into the VMN, so that oestrogen signals would only be blocked there and nowhere else in the body. The effect was dramatic - the females refused to have sex.

“They became extremely aggressive towards males, and started biting and kicking when males approached,” says Ogawa. The females refused to mate and none of them showed the usual signs of sexual receptivity. By contrast, control females injected with neutral RNAs mated as usual.

“Disruption of normal oestrogen signalling only in this region while leaving it intact elsewhere in the brain and the rest of the body is sufficient to completely block normal female courtship behaviour,” says Ogawa.

She says that the VMN has long been suspected to be the seat of female desire, but experiments in mice genetically engineered to have no oestrogen receptor alpha anywhere in the body failed to prove this because they affected all receptors, not just those in the VMN. Blocking signals just in the VMN has now shown “unambiguously” that this is where female sexual behaviour is controlled, say the researchers.  Link

Comments

[OINK]

In a follow-up to the mouse experiment , the researchers plan to investigate the effect on human females of a diet of rancid cheese.

[geekybob]

Scientists were able to stop oestrogen from reaching the VMN by feeding the mice wedding cake. Mice in a control group, fed birthday cake, mated as usual.

[Flavius Maximus]

Actually, all it has shown is that this is true of mice. It is foolish and unscientific to extend it to humans without specific studies.

[DrLang]

Actually, all it has shown is that this is true of mice. It is foolish and unscientific to extend it to humans without specific studies.

Actually many things in mouse brain anatomy and chemistry extend to humans. The cause of Parkinsins disease was first discovered in rats. Note the article said this is LIKELY that this is the the center of sexual desire in human females. They arn't so crazy as to declare it as fact until further human studies have been done.

[Cute]

Give me a fucking break. Nice fucking pictures. They are about as funny as some stupid "male/female remote control" joke spam.

Shove your fascist cunt book up your ass. Like someone who calls for violence knows anything about god.

[skeptic]

How do they know that the virus which affects that part of the brain didn't cause the response, as opposed to the receptor blocking? It seems as though they needed a third control group having the virus was injected with no horomone blocker. The study only proved that they know how to make female mice aggressive and irritable, but never defined whether the virus or the horomone blocking was responsible.

[Steel]

Oh my, someone woke up on the wrong side of the bed this morning - DIDN'T THEY?

Since you are new around here let me explain the rules.

They are very few and extremely simple.

I am Steel.

The is The Steel Deal.

That means I am kinda like the card dealer 'round here.

Actually, I do live in Reno NV.

Let's see which card I deal to YOU.

Oh my ... it is the GO FUCK YOURSELF card.

Bad luck for you.

So sorry.

Try again next time.

And in the meantime, stop by anytime.

Just keep you mouth shut - your ass is showin through.

[Steel]

I didn't even know they had broken the blood/brain barrier myself.

[Phoenix]

>Shove your facist cunt book up your ass.

Obviously, Cute's head is up hers. She just wants company. hahahahahaha!

I like the 'oil into the car' bit. It would be microscopic on my brain. (Although I do take care of my cars. It's just guided by knowledge, not instinct.)

oooooooh.... hahahahahaha. The comments are too funny!!! Why are people such fools about this stuff?

Using mice to study this is good. You wouldn't want to use actual humans, for crying out loud. Can't be having a bunch of 'control group' womens out humping everything in the lab including the radiator and fire extinguishers.

oh dear.... have to run.... my shoe-buying center has been activated..... or maybe it's the ice cream sundae center. Doesn't matter - it's P L E A S U R E I'm after, don't. you. know. LOL !!!!!! Oh. WAIT. Bring me a nice Manolo Blahnik hardon with a cherry on top. ....considering mine's long gone.......

[Phoenix]

>the VMN has long been suspected to be the seat of female desire, but experiments in mice genetically engineered to have no oestrogen receptor alpha anywhere in the body failed to prove this because they affected all receptors, not just those in the VMN<

This should answer your observation, Skeptic. As well, the females became irritated only when the males tried to mate. Otherwise, the female mice gossiped and talked about shoes with the other mice and and were very friendly.

[God]

>Shove your fascist cunt book up your ass. Like someone who calls for violence knows anything about god.<

Cute,

Kindly capitalize my name before I beat your head-stuffed ass. I love violence. I wrote a great book with a lot of violence in it. Check it out sometime.

[Richard]

I usually have a sense of humor about these things, but this is pathetic. Who wrote this crap article? huh huh, women are trophies. I like pissing all over the place and can't be bothered to clean up after myself because these are the only gender roles I understand. I contribute by occasionally fixing something and then making snide comments about how lucky the little lady is to have me. That's because I'm the enlightened one. I know what a Serpentine belt is and that is a constant reminder of my superiority over women. Are we really still stuck in the fifties? What kind of desperate societal recidivism is this?

[Jesus Christ]

Yeah! What HE said!

[Steel]

Oh my!

Somebody ELSE woke up on the wrong side of the bed.

Let's what card Richard gets ...

Oops, another GO FUCK YOURSELF card.

I must've stacked the deck.

Better luck next time.

[Richard]

Cute Steel, very cute. Get a job.

[Steel]

You voted for Kerry didn't you?

HAHAHAHAHAHAHAHA.

Too bad.

Better luck next time.

Try again.

[Richard]

Beats the hell out of selling your friends to the US Government in exchange for a fat profit by Haliburton and the Carlyle group. Kerry wasn't much of aleader. At least Bush has a Houdini-like ability to disguise his shadiness behind a thin venire of "honest simplicity". It's a rigged game, but I keep playing because it's the only game in town. Nobody remembers that Bush's daddy profiteered on the war, but they all remember that he's been "misunderestimated."

[Janesatool]

You're a douchebag. YOu're also a very shallow man, whom has probably never dated a women with an IQ above 60. Do you want a crowbar to help you remove your head from your ass?

[Ungood]

In the 1970's, similar experiments in human subjects were a complete failure.

The female human subjects injected with VMN only wanted to eat cheese and watch Hawaii 5-0

[Steel]

That mantra and .50 will get you another card Richard.

But I think I can divine what it might be.

You've been listening to too much NPR and watching too much Jon Stewart.

Rotted your brain.

I hear they'll take you in the military until you're 42 now.

They might help unplug your head from your ass.

Failing that, I recommend a full rectal lobotomy.

[Steel]

Janesatool ...

Ya got spellchek on that there machine?

Take 'er out fer a spin.

See how she runs.

[Richard]

Had any friends die in Iraq? No? Didn't think so. Do you even know anyone over there? No again? Not really surprising. It never ceases to amaze me that the lower classes will actively choose people who are acting against their best interests as long as that person doesn't intimidate them with their intelligence or alienate them with their well reasoned arguments. In the constantly repeated words of your parents, first when you dropped out of high school, then again when you impregnated your sister, "I'm not angry. I'm just disappointed."

[Richard]

Here's a little piece for you on your own little idol, Coulter.
http://worshiptheglitch.com/2006/06/henry-rollins-love-letter-to-ann.html

[Steel]

Wrong on all accounts Richard, which certainly comes as no surprise to me.

Every been in the military?

Naw, I didn't think so.

I have.

When your poppa was dodgin' the draft.

I've taught post graduate level, Dick.

You?

Naw, I didn't think so.

I feel a card trick comin' on ...

Pick a card - any card.

Okay, now, look at it and don't tell me what it is.

__________________________________________________

It's the GO FUCK YOURSELF card isn't it?

Damn I'm good.

[Steel]

Rollins is good man.

He ain't a pussy like you.

BTW. You need some help with that HTML?

All this time, I thought having my very own troll would be ... somehow, more fun.

Maybe it's the quality of the troll.

Yeah, that's it.

You suck.